THE MOST RELIABLE AND CUSTOMIZABLE SOLUTION IN THE NUTRACEUTICAL FIELD
Natural ingredients have great potential for human wellbeing. Their healthy effects are well known since centuries, through the traditional medicines, and have also been studied with scientific approach in the modern nutraceutical field.
On the other hand, most of the phytonutrients cannot reveal all their possible benefits because of their low oral bioabsorption. 
Indena started working over 20 years ago to solve this issue and make its botanical extracts actually very effective and safe. Thanks to its research and development activity, Indena was able to find and implement the most reliable and customizable solution in the nutraceutical field: Indena Phytosome™, the proprietary multitalented technology platform, a breakthrough 100% food-grade delivery system that optimizes the botanical performance, benefits and power of phytonutrients.
As supported by numerous rigorous scientific studies, Indena Phytosome™ can:
optimize bio-absorption of many phytonutrients

• help  get to the target organ
• help protect the extract from oxidation and helps stability
• help  minimize variation subject to subject
• optimize interaction with microbiome
• improve the botanical extract tolerability.

INDENA PHYTOSOME™ HOW IT WORKS?
Indena Phytosome™ is a solid dispersion of botanicals or natural compounds into a 100% food-grade matrix based on lecithin, amphipathic molecules which act as inhibitor of self-aggregation and effective wetting agents.
Indena Phytosome™ is formulated exclusively with natural dietary ingredients (phospholipids) that act as vectors dynamically reducing the self-aggregation of natural compounds. 
In fact, phospholipids and botanicals, on their own, naturally tend to self-aggregate. In particular, the first aim to join into well-organized structures, while the second aggregate in an inefficient way creating clusters that make the final formulation unstable and rigid. Bi-directional actions are required then, for natural compounds and phospholipids to mutually avoid packing that would reduce absorption by the human body. Phospholipids enclosed in Indena Phytosome™ formula interact with botanical compounds and inhibit their self-aggregation, defeating the primary limit to the full exploitation of phytonutrients’ potential. In turn, botanical compounds avoid the self-aggregation of phospholipids. 
The result is the achievement of a stable and solid dispersion which allows botanicals to give their best.
Indena Phytosome™ is a “functional solid dispersion” of botanicals into lecithin and allows natural compounds to efficiently interact with the gut ecosystem in terms of absorption and microbiota interactivity. It thus optimizes bioabsorption without relying on pharmacological adjuvants or structural modification of the ingredients, maintaining tolerability and safety over time.
Indena Phytosome™  is a tailor made composition, to obtain a not well organized, but stable dispersion of phospholipids and our botanical ingredient.

WHAT INDENA PHYTOSOME™ IS NOT
Indena Phytosome™ formulations AREN’T:

• chemical derivatives or new chemical entities: no covalent bond is involved in their formation;
• complexes: no well-defined, three-dimensional association between lecithin and the dispersed nutraceutical exists, but lecithin, an amphipathic compound, simply acts as a self-aggregation inhibitor, facilitating dispersion in biological media;
• liposomes, which differ in structure, manufacturing process and stability showing a well-defined micellar or vesicular structure 
• nanoformulations: no ultra-dispersion method is involved in their formation.

A TAILOR-MADE FORMULATION DESIGN 
Not all the Indena Phytosome™are the same. 
Each Indena Phytosome™ formulation is specifically designed to optimize individual characteristics of the final ingredient by modulating several factors, such as: extract-lecithin ratio, particle size, solvent, lecithin origin, process temperature, volume of solvents and addition of food additives.
As for dosage forms, Indena Phytosome™ formulations are compatible not only with conventional dosage forms like film-coated tablets, hard gelatin capsules and water suspensions (water dispersible powder), but they may also be proponed as smart finished products including chewable tablets, gummies & oral gels.

SCIENCE BEHIND
Indena Phytosome™ is unique, supported by many scientific studies and clinical evidences: it is the science-based original one. It is a very effective delivery system, based on decades of experience and pioneering innovation by Indena and coming from a high quality industrial scale production. 
Over 4 billion servings delivered globally*: this is the most powerful demonstration of Indena Phytosome™distinctiveness, efficacy and quality. 

CONTACTS
Laura Bo - External Communication

laura.bo@indena.com