Panel discussion on...
Pet Supplements
David Foreman
President, Herbal Pharmacist Media

Member of AgroFOOD Industry Hi Tech's Scientific Advisory Board

In this Panel Discussion, several prominent companies within the food and nutraceutical ingredient industry have been invited to discuss about drivers and barriers of healthy lifestyle, focusing on global and regional consumer trends, scientific achievements, emerging delivery formats, use of AI technologies and the implementation of the United Nations sustainability goals.
1A) The biggest gap is species-specific clinical validation. In human nutrition, we often have decades of mechanistic, pharmacokinetic, and outcome data. In pets, we still rely too heavily on extrapolation. We need more clarity on absorption differences, microbiome interactions, metabolism, and long-term safety in dogs and cats. Pets are not small humans, and their physiology proves it every day.
1B) Species-specific research is critical. Human data can help establish mechanistic plausibility, but it should never be the finish line. Dogs and cats process nutrients differently, have distinct gut microbiomes, and age on different biological timelines. Human data may guide ingredient selection, but pet-specific dosing, safety, and outcome data are essential for credibility.
1D) Three factors stand out: standardization, purity, and bioavailability. Pets often receive smaller doses, so batch-to-batch consistency is even more critical. Purity is critical because pets can be more sensitive to contaminants. Bioavailability is often overlooked—but if the ingredient isn’t absorbed or utilized, it doesn’t matter how good it looks on paper.
1F) At a minimum, we should expect well-designed pilot or observational studies in the target species, supported by a strong mechanistic rationale and safety data. Gold-standard, large-scale trials are ideal but not always feasible. What matters is transparent study design, relevant endpoints, and honest interpretation, not borrowed claims or over-promising.
1G) Claims around mobility, cognition, calm behavior, and gut health are often misunderstood. Consumers may interpret “supports joint health” as “fixes arthritis.” This risk is reduced through plain-language education, clearly defined benefits, and by aligning claims with observable, everyday outcomes, such as comfort, activity, or digestion, rather than with medical expectations.
1H) Variability is the biggest challenge; breed, size, age, diet, and environment all influence outcomes. These challenges can be addressed through clear inclusion criteria, standardized feeding protocols, validated scoring tools, and longer study durations. Collaboration with veterinary researchers is also essential to maintain scientific rigor.
1I) Owner-reported outcomes are valuable because they capture real-world, day-to-day changes, but they can be subjective. Veterinary assessments provide objectivity. The best studies combine validated owner questionnaires with veterinary exams, biomarkers, or functional measures to create a more complete picture.
1L) Absolutely. There’s growing interest in ingredients that support mobility, digestive efficiency, immune resilience, and cognitive function as pets live longer. Healthy aging is no longer about “fixing problems” but about maintaining quality of life earlier and longer, mirroring trends we’ve already seen in human nutrition.
4A) Credibility will be driven by science-backed ingredients, transparent sourcing, responsible claims, and education, not hype. Brands that invest in species-specific research and long-term safety data will stand out. The future belongs to companies that treat pet nutrition with the same seriousness we expect in human health.
4B) Education. Clear, honest education that explains what an ingredient does, what it doesn’t do, and why it matters. When brands stop talking over consumers and start teaching them, trust follows. In my experience, informed pet parents don’t want miracles; they want truth.
Panelists
References and notes
- Kovalkovičová, N et al. 2009. Some food toxic for pets. Interdiscip Toxicol. 2(3):169–176. https://doi.org/10.2478/v10102-009-0012-4
- Beleć, K et al. 2025. The Effect of the Type and Concentration of Garlic (Allium sativum) on Heinz Body Concentrations in Canine Erythrocytes—An In Vitro Study. Animals, 15, 3188. https://doi.org/10.3390/ani15213188
- Benyacoub, J. et al. 2003. Supplementation of Food with Enterococcus faecium (SF68) Stimulates Immune Functions in Young Dogs. J. Nutr. 133: 1158-62. https://doi.org/10.1093/jn/133.4.1158
- Bednorz, C. et al. 2013. Feeding the Probiotic Enterococcus faecium Strain NCIMB 10415 to Piglets Specifically Reduces the Number of Escherichia coli Pathotypes That Adhere to the Gut Mucosa. Appl. Environ. Microbiol. 79(24):7896-7904. https://doi.org/10.1128/AEM.03138-13
- Benvenuti, L. et al. 2023. Dietary Supplementation with the Probiotic SF68 Reinforces Intestinal Epithelial Barrier in Obese Mice by Improving Butyrate Bioavailability. Mol. Nutr. Food Res. 67(13): 2200442. https://doi.org/10.1002/mnfr.202200442
- Beirão, B. C. B. et al. 2018. Effect of an Enterococcus faecium probiotic on specific IgA following live Salmonella Enteritidis vaccination of layer chickens. Avian Pathology, 47(3), pp. 325–333. https://doi.org/10.1080/03079457.2018.1450487
- Bybee, S. N. et al. 2011. Effect of the Probiotic Enterococcus faecium SF68 on Presence of Diarrhea in Cats and Dogs Housed in an Animal Shelter. J Vet Intern Med. Jul-Aug;25(4):856-60. https://doi.org/10.1111/j.1939-1676.2011.0738.x
- Regulation - 1831/2003 - EN - EUR-Lex
Questions
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Ingredients companies - clinical data
A) What are the main scientific gaps that still exist in PET supplement development compared to human dietary supplements?
B) How important is species-specific research when selecting and developing active ingredients for pets? Can human data ever be sufficient?
C) Is the humanization of pets helping consumers make better-informed choices, or does it risk creating unrealistic expectations about supplement performance?
D) From an ingredient supplier’s perspective, which quality parameters (standardization, bioavailability, purity) are most critical for PET applications?
E) How are trends such as “clean label,” sustainability, and transparency influencing pet owners’ purchasing decisions in the PET supplement space?
F) What type of clinical evidence should realistically be expected to support PET supplement claims today?
G) Which types of claims are most likely to be misunderstood by consumers, and how can this risk be reduced through clearer substantiation and labeling?
H) What are the main methodological challenges in conducting clinical trials for companion animals, and how can they be addressed?
I) How reliable are owner-reported outcomes compared to veterinary assessments, and how should they be integrated into study design?
L) Have you noticed an increasing trend in the use of one (or more) ingredients for pet supplements formulated to promote healthy ageing?
Formulation
A) What are the biggest formulation challenges in PET supplements, particularly regarding palatability, stability, and dosing accuracy?
B) How do formulation choices (e.g., chews, powders, liquids) influence compliance and consistent use from a consumer perspective?
C) Do you see a shift toward simpler, single-ingredient formulations, or are multi-active blends still the dominant approach? Why?
D) How do species differences (dogs vs cats, size, age) influence formulation strategies?
E) Omega 3 alternatives for pet nutrition and sustainability: how do the innovative omega-3s for pet food stack up against their traditional fishy counterparts?
Regulation
A) How do regulatory frameworks for PET supplements differ between the EU and the US, and what challenges do these differences create for global brands?
B) Which types of claims represent the highest regulatory risk today, and which are more likely to be acceptable if properly substantiated?
C) Do you expect regulatory oversight of PET supplements to become stricter in the coming years? Why or why not?
D) What role should veterinarians play in guiding pet owners’ choices regarding PET supplements, and how can trust between brands, vets, and consumers be strengthened?
Open questions
A) Looking ahead 5–10 years, what will be the key factors determining the credibility and long-term success of the PET supplements sector?
B) In your view, what single change—scientific, regulatory, or educational—would most improve consumer trust in PET supplements over the next decade?
References and notes










